Feature
Melatonin
5-HTP
Typical Dosage
0.5–5 mg
50-100mg per day
Best Form
Immediate release tablet
Capsule
Key Benefits
5
5
Evidence Rating
★★★★
★★★
Best Time
30–60 minutes before bedtime
Take with meals in divided doses, typically in the evening for sleep support
Melatonin Benefits
✓Improved sleep onset and quality
✓Jet lag reduction
✓Circadian rhythm regulation
✓Antioxidant protection
✓Shift work sleep disorder management
5-HTP Benefits
✓Mood support and depression relief
✓Improved sleep quality
✓Appetite suppression and weight management
✓Migraine prevention
✓Anxiety reduction
Can You Take Both Together?
In most cases, Melatonin and 5-HTP can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication.
Which Should You Choose?
Choose Melatonin if your primary goal is: improved sleep onset and quality. Choose 5-HTP if your primary goal is: mood support and depression relief. Many people take both as they target different aspects of health.
Disclaimer: This comparison is for educational purposes only. Always consult a healthcare professional before starting any supplement.