5-HTP
amino acids
5-HTP (5-hydroxytryptophan) is an amino acid precursor to serotonin, derived from the seeds of Griffonia simplicifolia. It is commonly used as a supplement to support mood, sleep quality, and appetite regulation by increasing serotonin levels in the brain.
Ready to try 5-HTP?
Shop top-rated 5-HTP supplements on Amazon UK
Affiliate link — we may earn a small commission at no extra cost to you.
Benefits
Dosage
Typical Dose
50-100mg per day
Upper Limit
300mg per day
Timing
Take with meals in divided doses, typically in the evening for sleep support
Forms & Bioavailability
Capsule
Standard absorption, well-tolerated form
Tablet
Similar bioavailability to capsules, convenient dosing
Side Effects
Interactions
Research Summary
Clinical studies demonstrate 5-HTP's efficacy in improving mood and reducing depressive symptoms, with several trials showing benefits comparable to certain SSRIs. Research supports its use for sleep improvement and appetite regulation, though evidence quality varies. However, long-term safety data is limited, and concerns regarding eosinophilia-myalgia syndrome associations warrant cautious use.
Compare 5-HTP with...
The Bottom Line on 5-HTP
5-HTP is moderately researched with promising but sometimes mixed evidence.It is most commonly used for mood support and depression relief and improved sleep quality. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
Top Rated 5-HTP on Amazon UK
We recommend choosing products with 4+ star ratings and verified reviews. Look for third-party tested brands.
Affiliate links — we earn a small commission at no extra cost to you.
Where to Buy 5-HTP
We recommend buying from reputable retailers. Check reviews and third-party testing.
Affiliate links — we may earn a commission at no extra cost to you.
Shop From Our Partners
Amazon UK
Browse 5-HTP supplements
Tonic Health
Vitamin C, D3 & Zinc sachets
NAD Direct
NAD+ & cellular health
Space Goods
Nootropic mushroom blends
Affiliate links — we may earn a commission at no extra cost to you.