Best Supplements for Longevity
Longevity science targets the hallmarks of aging: genomic instability, telomere shortening, mitochondrial dysfunction, cellular senescence, and inflammation. These supplements address multiple aging pathways based on current research.
Top 5 Recommended Supplements
NMN
500-1,000mgDirect NAD+ precursor. NAD+ declines 50% by age 50, impairing sirtuin activity, DNA repair, and mitochondrial function
Buy on Amazon →Resveratrol
500mg trans-resveratrolSIRT1 activator. Mimics caloric restriction benefits. Synergistic with NMN for longevity pathway activation
Buy on Amazon →Quercetin + Fisetin
500mg + 100mgSenolytic combination that clears senescent (zombie) cells. These cells drive aging through inflammatory SASP secretion
Buy on Amazon →Omega-3 Fish Oil
3g EPA/DHAReduces chronic inflammation (inflammaging). Telomere length preservation. Cardiovascular and brain protection
Buy on Amazon →Vitamin D3 + K2
5,000 IU + 200mcgDeficiency accelerates aging. Regulates 1,000+ genes. K2 prevents calcium misdirection. Foundational for longevity
Buy on Amazon →Sample Daily Stack
Morning fasted: NMN (500mg) sublingual + Resveratrol (500mg) with olive oil
With breakfast: Omega-3 (3g) + Vitamin D3 (5,000 IU) + K2 (200mcg)
Monthly senolytic pulse: Quercetin (1,000mg) + Fisetin (500mg) for 2 consecutive days
Daily foundation: Exercise, sleep, stress management, nutrient-dense diet
Lifestyle Tips
Caloric restriction or time-restricted eating activates longevity pathways
Zone 2 cardio (3-4 hours/week) is the strongest longevity exercise
Strength training 2-3x/week preserves muscle mass and metabolic health
Build and maintain social connections — loneliness reduces lifespan by 15 years
Annual comprehensive blood work: metabolic panel, hormones, inflammatory markers
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Try Huel →This information is for educational purposes only and does not constitute medical advice. Supplement recommendations are based on published research but individual needs vary. Always consult a qualified healthcare professional before starting any supplement regimen. Amazon links are affiliate links.