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Citrulline Malate 2:1 vs L-Theanine — Which Should You Take?

Citrulline Malate 2:1

amino acids

Typically £8–£25/month

L-Theanine

nootropics

Typically £8–£25/month
Feature
Citrulline Malate 2:1
L-Theanine
Typical Dosage
6-8 grams per day
100-200mg daily
Best Form
Powder
L-Theanine (Suntheanine)
Key Benefits
5 listed
5 listed
Evidence Rating
★★★★
★★★★
Best Time
30-60 minutes before exercise for optimal effect
With caffeine for focus, or evening for relaxation
Upper Limit
16 grams per day
400mg daily
Side Effects
3 noted
3 noted

Citrulline Malate 2:1 Benefits

Enhanced exercise performance and endurance
Reduced muscle fatigue and soreness
Improved blood flow and nitric oxide production
Increased ATP energy production
Support for recovery and stamina

L-Theanine Benefits

Calm focus without sedation
Reduces caffeine jitters when combined
Promotes alpha brain waves (relaxed alertness)
May improve sleep quality
Anxiety reduction

Citrulline Malate 2:1 Side Effects

Gastrointestinal discomfort or nausea at high doses
Diarrhoea or loose stools
Mild stomach upset or cramping

L-Theanine Side Effects

Very few — one of the safest supplements
Mild drowsiness at high doses
May lower blood pressure slightly

Can You Take Citrulline Malate 2:1 and L-Theanine Together?

In most cases, Citrulline Malate 2:1 and L-Theanine can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication or have existing health conditions.

Citrulline Malate 2:1: May potentiate blood pressure-lowering medications

Citrulline Malate 2:1: Potential interaction with erectile dysfunction medications

L-Theanine: Caffeine — synergistic (the classic nootropic stack)

L-Theanine: Blood pressure medications — additive hypotensive effect

Which Should You Choose?

Choose Citrulline Malate 2:1 if your primary goal is: enhanced exercise performance and endurance. Choose L-Theanine if your primary goal is: calm focus without sedation.

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Frequently Asked Questions

Is Citrulline Malate 2:1 better than L-Theanine?

It depends on your goals. Citrulline Malate 2:1 and L-Theanine serve different purposes and are often taken together.

Can I take Citrulline Malate 2:1 and L-Theanine together?

In most cases, yes. Citrulline Malate 2:1 and L-Theanine can be taken together safely. However, always check for specific interactions and consult a healthcare professional if you take medication.

What is the best time to take Citrulline Malate 2:1?

30-60 minutes before exercise for optimal effect

What is the best time to take L-Theanine?

With caffeine for focus, or evening for relaxation

What are the side effects of Citrulline Malate 2:1?

Gastrointestinal discomfort or nausea at high doses. Diarrhoea or loose stools. Mild stomach upset or cramping.

What are the side effects of L-Theanine?

Very few — one of the safest supplements. Mild drowsiness at high doses. May lower blood pressure slightly.

How We Compare Supplements

This comparison is based on published clinical research, peer-reviewed studies from PubMed, and established nutritional science. We evaluate dosages based on clinically-effective amounts, not manufacturer recommendations. Benefits listed have at least moderate evidence from human studies. When evidence is limited or conflicting, we note this.

Disclaimer: This comparison is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting any supplement, especially if you take medication or have existing health conditions.

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