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Devil's Claw vs Ashwagandha (KSM-66) — Which Should You Take?

Devil's Claw

herbs

Typically £8–£25/month

Ashwagandha (KSM-66)

adaptogens

Typically £8–£25/month
Feature
Devil's Claw
Ashwagandha (KSM-66)
Typical Dosage
1.5-3g dried root daily
300-600mg daily (KSM-66 extract)
Best Form
dried root powder
KSM-66
Key Benefits
5 listed
5 listed
Evidence Rating
★★★★★
★★★★
Best Time
with meals to minimise gastrointestinal upset
Evening for sleep, or split morning/evening for stress
Upper Limit
10g daily
1,200mg daily
Side Effects
5 noted
4 noted

Devil's Claw Benefits

joint-health
anti-inflammatory
pain-relief
arthritis-support
mobility

Ashwagandha (KSM-66) Benefits

Reduces cortisol and perceived stress
Improves sleep quality
May increase testosterone in men
Anxiety reduction
Physical performance enhancement

Devil's Claw Side Effects

nausea
diarrhoea
abdominal discomfort
loss of appetite
allergic reactions (rare)

Ashwagandha (KSM-66) Side Effects

Drowsiness (dose-dependent)
May worsen thyroid conditions (can increase thyroid hormones)
Mild digestive upset in some people
Not recommended during pregnancy

Can You Take Devil's Claw and Ashwagandha (KSM-66) Together?

In most cases, Devil's Claw and Ashwagandha (KSM-66) can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication or have existing health conditions.

Devil's Claw: may interact with gastric acid-reducing medications

Devil's Claw: potential interaction with anticoagulants

Ashwagandha (KSM-66): Thyroid medications — may increase thyroid hormone levels

Ashwagandha (KSM-66): Sedatives — additive drowsiness

Which Should You Choose?

Choose Devil's Claw if your primary goal is: joint-health. Choose Ashwagandha (KSM-66) if your primary goal is: reduces cortisol and perceived stress.

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Frequently Asked Questions

Is Devil's Claw better than Ashwagandha (KSM-66)?

It depends on your goals. Devil's Claw and Ashwagandha (KSM-66) serve different purposes and are often taken together.

Can I take Devil's Claw and Ashwagandha (KSM-66) together?

In most cases, yes. Devil's Claw and Ashwagandha (KSM-66) can be taken together safely. However, always check for specific interactions and consult a healthcare professional if you take medication.

What is the best time to take Devil's Claw?

with meals to minimise gastrointestinal upset

What is the best time to take Ashwagandha (KSM-66)?

Evening for sleep, or split morning/evening for stress

What are the side effects of Devil's Claw?

nausea. diarrhoea. abdominal discomfort. loss of appetite. allergic reactions (rare).

What are the side effects of Ashwagandha (KSM-66)?

Drowsiness (dose-dependent). May worsen thyroid conditions (can increase thyroid hormones). Mild digestive upset in some people. Not recommended during pregnancy.

How We Compare Supplements

This comparison is based on published clinical research, peer-reviewed studies from PubMed, and established nutritional science. We evaluate dosages based on clinically-effective amounts, not manufacturer recommendations. Benefits listed have at least moderate evidence from human studies. When evidence is limited or conflicting, we note this.

Disclaimer: This comparison is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting any supplement, especially if you take medication or have existing health conditions.

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