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Glycine vs Ashwagandha (KSM-66) — Which Should You Take?

Glycine

amino acids

Typically £8–£25/month

Ashwagandha (KSM-66)

adaptogens

Typically £8–£25/month
Feature
Glycine
Ashwagandha (KSM-66)
Typical Dosage
3-5g daily
300-600mg daily (KSM-66 extract)
Best Form
Powder
KSM-66
Key Benefits
6 listed
5 listed
Evidence Rating
★★★★
★★★★
Best Time
Evening for sleep benefits; anytime for general health
Evening for sleep, or split morning/evening for stress
Upper Limit
10g daily
1,200mg daily
Side Effects
3 noted
4 noted

Glycine Benefits

Improves sleep quality and sleep onset
Supports collagen formation and joint health
Enhances cognitive function and memory
Reduces muscle wasting and supports muscle recovery
Promotes relaxation and reduces anxiety
Supports immune function

Ashwagandha (KSM-66) Benefits

Reduces cortisol and perceived stress
Improves sleep quality
May increase testosterone in men
Anxiety reduction
Physical performance enhancement

Glycine Side Effects

Mild gastrointestinal upset at high doses
Drowsiness (particularly at evening dosing)
Fatigue in some individuals

Ashwagandha (KSM-66) Side Effects

Drowsiness (dose-dependent)
May worsen thyroid conditions (can increase thyroid hormones)
Mild digestive upset in some people
Not recommended during pregnancy

Can You Take Glycine and Ashwagandha (KSM-66) Together?

In most cases, Glycine and Ashwagandha (KSM-66) can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication or have existing health conditions.

Glycine: May potentiate sedative effects with benzodiazepines or sleep medications

Glycine: Possible interaction with antipsychotic medications

Ashwagandha (KSM-66): Thyroid medications — may increase thyroid hormone levels

Ashwagandha (KSM-66): Sedatives — additive drowsiness

Which Should You Choose?

Choose Glycine if your primary goal is: improves sleep quality and sleep onset. Choose Ashwagandha (KSM-66) if your primary goal is: reduces cortisol and perceived stress.

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Frequently Asked Questions

Is Glycine better than Ashwagandha (KSM-66)?

It depends on your goals. Glycine and Ashwagandha (KSM-66) serve different purposes and are often taken together.

Can I take Glycine and Ashwagandha (KSM-66) together?

In most cases, yes. Glycine and Ashwagandha (KSM-66) can be taken together safely. However, always check for specific interactions and consult a healthcare professional if you take medication.

What is the best time to take Glycine?

Evening for sleep benefits; anytime for general health

What is the best time to take Ashwagandha (KSM-66)?

Evening for sleep, or split morning/evening for stress

What are the side effects of Glycine?

Mild gastrointestinal upset at high doses. Drowsiness (particularly at evening dosing). Fatigue in some individuals.

What are the side effects of Ashwagandha (KSM-66)?

Drowsiness (dose-dependent). May worsen thyroid conditions (can increase thyroid hormones). Mild digestive upset in some people. Not recommended during pregnancy.

How We Compare Supplements

This comparison is based on published clinical research, peer-reviewed studies from PubMed, and established nutritional science. We evaluate dosages based on clinically-effective amounts, not manufacturer recommendations. Benefits listed have at least moderate evidence from human studies. When evidence is limited or conflicting, we note this.

Disclaimer: This comparison is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting any supplement, especially if you take medication or have existing health conditions.

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