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Foundational

Best Supplements for Inflammation Reduction

Chronic low-grade inflammation (inflammaging) underlies nearly every disease of aging. Reducing systemic inflammation improves every health outcome from heart disease to neurodegeneration.

Top 5 Recommended Supplements

1

Omega-3 Fish Oil

3-4g EPA-heavy

EPA produces resolvins and protectins that actively resolve inflammation, rather than just suppressing symptoms

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2

Curcumin (Phytosome)

1,000mg

Inhibits NF-kB (master inflammatory switch) more effectively than many pharmaceuticals in vitro. Use bioavailable form

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3

Boswellia (AKBA)

300-500mg

Inhibits 5-LOX (unique mechanism different from curcumin's NF-kB). Synergistic when combined with curcumin

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4

SPMs (Specialised Pro-Resolving Mediators)

1-2g

Derived from omega-3s. Directly resolve inflammation rather than just blocking it. The resolution phase of inflammation

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5

Ginger Extract

500mg

Inhibits COX-2 and LOX enzymes, reduces prostaglandins. Studies show comparable efficacy to ibuprofen for certain pains

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Sample Daily Stack

1

Morning: Omega-3 (2g EPA) + Curcumin Phytosome (500mg) with breakfast

2

Afternoon: Boswellia (300mg) + Ginger (500mg) with lunch

3

Evening: Omega-3 (2g EPA) + Curcumin Phytosome (500mg) with dinner

4

Add SPMs during flare-ups: 2g for 2 weeks

Lifestyle Tips

Eliminate processed seed oils (soybean, corn, canola) — they promote omega-6 driven inflammation

Eat an anti-inflammatory diet: wild fish, colourful vegetables, olive oil, berries

Exercise is anti-inflammatory when not overdone (150 min moderate per week)

Sleep deprivation increases CRP and IL-6 — prioritise 7-9 hours

Measure CRP, ESR, and homocysteine to track inflammation levels

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This information is for educational purposes only and does not constitute medical advice. Supplement recommendations are based on published research but individual needs vary. Always consult a qualified healthcare professional before starting any supplement regimen. Amazon links are affiliate links.

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