Best Supplements for Longevity Protocol Stack
A comprehensive longevity stack targets the hallmarks of aging through multiple complementary mechanisms: NAD+ restoration, senolytic clearance, mitochondrial support, and inflammation control.
Top 5 Recommended Supplements
NMN
500-1,000mgNAD+ precursor for sirtuin activation, DNA repair, and mitochondrial function
Buy on Amazon →Resveratrol
500mg trans-resveratrolSIRT1 activator that synergises with NMN for longevity pathway activation
Buy on Amazon →Quercetin + Fisetin
500mg + 100mgSenolytic combination for monthly clearing of senescent cells
Buy on Amazon →Omega-3 Fish Oil
3gAnti-inflammatory foundation. Telomere preservation. Cardiovascular and brain protection
Buy on Amazon →Spermidine
1-5mgThe only dietary autophagy activator with human observational longevity data
Buy on Amazon →Sample Daily Stack
Morning fasted: NMN (500mg sublingual) + Resveratrol (500mg with olive oil)
With breakfast: Omega-3 (3g) + Vitamin D3 (5,000 IU) + K2 (200mcg) + Spermidine
Monthly senolytic pulse: Quercetin (1,000mg) + Fisetin (500mg) for 2 consecutive days
Daily foundation: Exercise, 8h sleep, time-restricted eating, stress management
Lifestyle Tips
The Big 5 lifestyle factors matter more than any supplement: sleep, exercise, nutrition, stress, social connection
Zone 2 cardio 3-4h/week is the strongest longevity exercise intervention
Strength training 2-3x/week preserves muscle mass and metabolic health
Annual comprehensive blood work to track biological age markers
Caloric restriction or time-restricted eating (16:8) activates longevity pathways
Recommended
This information is for educational purposes only and does not constitute medical advice. Supplement recommendations are based on published research but individual needs vary. Always consult a qualified healthcare professional before starting any supplement regimen. Amazon links are affiliate links.