Best Supplements for Migraine Prevention
Migraines involve cortical spreading depression, trigeminal nerve activation, and neuroinflammation. These supplements have strong evidence for reducing migraine frequency and severity.
Top 5 Recommended Supplements
Magnesium
400-600mgMigraine sufferers often have low brain magnesium. Supplementation reduces frequency by 41% in clinical trials
Buy on Amazon →Riboflavin (B2)
400mgImproves mitochondrial energy production in neurons. RCTs show 50% reduction in migraine frequency after 3 months
Buy on Amazon →CoQ10
300mgSupports neuronal mitochondrial function. Studies show 50% reduction in migraine days. Particularly effective in children/teens
Buy on Amazon →Feverfew
100-300mg (parthenolide standardised)Inhibits serotonin release and prostaglandin synthesis. Traditional migraine herb with clinical trial support
Buy on Amazon →Butterbur
75mg 2x daily (PA-free)Petadolex brand showed 48% reduction in migraine frequency. MUST be PA-free (pyrrolizidine alkaloids are hepatotoxic)
Buy on Amazon →Sample Daily Stack
Morning: Riboflavin (400mg) + CoQ10 (150mg) + Magnesium (200mg)
Afternoon: Feverfew (150mg) + CoQ10 (150mg)
Evening: Magnesium (400mg) + Butterbur (75mg PA-free)
Allow 3 months for full preventive effect to develop
Lifestyle Tips
Identify triggers: food diary tracking (common: aged cheese, wine, MSG, artificial sweeteners)
Maintain consistent sleep schedule — both too little and too much sleep trigger migraines
Stay hydrated — dehydration is a common trigger
Regular exercise reduces migraine frequency (but avoid sudden intense exercise)
Consider keeping a migraine diary to track frequency and identify patterns
Recommended
This information is for educational purposes only and does not constitute medical advice. Supplement recommendations are based on published research but individual needs vary. Always consult a qualified healthcare professional before starting any supplement regimen. Amazon links are affiliate links.