Fadogia Agrestis
herbs
Fadogia Agrestis is a Nigerian shrub traditionally used as an aphrodisiac that has gained mainstream attention through the Huberman Lab podcast. It is hypothesised to stimulate luteinising hormone (LH) release, which may increase testicular testosterone production. Despite viral popularity, human clinical data remains extremely limited, and animal studies have raised concerns about testicular toxicity at higher doses.
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Benefits
Dosage
Typical Dose
300-600mg daily
Upper Limit
600mg daily (no established safe upper limit in humans)
Timing
Morning with food; often cycled 8 weeks on, 2-4 weeks off
Forms & Bioavailability
Stem extract (10:1)
Moderate — most common supplemental form
Raw dried stem powder
Lower — variable alkaloid and saponin content
Side Effects
Interactions
Research Summary
Fadogia Agrestis research is almost entirely based on rodent studies. A 2005 study in the Journal of Ethnopharmacology showed dose-dependent increases in testosterone in male rats, but the same study noted testicular architectural changes at higher doses (100mg/kg). No published randomised controlled trials exist in humans as of 2025. Its popularity stems largely from the Huberman Lab podcast, where it was suggested alongside Tongkat Ali for testosterone support. Given the absence of human trials and the concerning animal toxicology data, supplementation should be approached with caution, ideally with regular bloodwork monitoring.
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The Bottom Line on Fadogia Agrestis
Fadogia Agrestis is emerging in research with limited but interesting evidence.It is most commonly used for may support luteinising hormone (lh) secretion and traditionally used as an aphrodisiac in west african medicine. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Fadogia Agrestis
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