Serrapeptase

herbs

★★★★★

Serrapeptase is a proteolytic enzyme derived from silkworm intestines that breaks down non-living tissue and fibrin. It is traditionally used in Asian medicine to reduce inflammation and support tissue healing, though clinical evidence in humans remains limited.

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Benefits

✓May reduce inflammation and swelling

✓Potential support for scar tissue breakdown

✓May improve circulation and blood flow

✓Could support respiratory health and mucus clearance

✓May assist post-surgical recovery and tissue repair

Dosage

Typical Dose

10-60 mg daily (20-40 mg most common)

Upper Limit

120 mg daily in divided doses

Timing

On empty stomach, 2 hours before or after meals for optimal absorption

Forms & Bioavailability

Enteric-coated tablets

High (acid-protected for intestinal absorption)

Capsules (enteric-coated)

High

Standard tablets

Low (destroyed by stomach acid)

Side Effects

⚠Mild gastrointestinal upset, nausea, or stomach pain

⚠Potential allergic reactions in individuals sensitive to silkworm proteins

⚠Rare bleeding or bruising if combined with anticoagulants

Interactions

⚡May potentiate anticoagulant and antiplatelet medications (warfarin, aspirin)

⚡Can interact with blood-thinning supplements (ginkgo, garlic, ginger)

⚡May enhance effects of other proteolytic enzymes if combined

Research Summary

Clinical evidence for serrapeptase in humans is limited and mixed. Most studies are small and conducted in Asian countries, with several showing modest benefits for inflammation and post-surgical swelling, though methodological quality varies. Further high-quality research in Western populations is needed to establish efficacy and optimal dosing protocols.

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The Bottom Line on Serrapeptase

Serrapeptase is moderately researched with promising but sometimes mixed evidence.It is most commonly used for may reduce inflammation and swelling and potential support for scar tissue breakdown. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Goal Guides for Serrapeptase

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.