Sulbutiamine
nootropics
Synthetic thiamine derivative that crosses the blood-brain barrier for cognitive support.
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Benefits
Dosage
Typical Dose
400-600mg daily
Upper Limit
200-800mg
Timing
Morning with food
Forms & Bioavailability
Capsule
Standard absorption
Powder
Standard absorption
Side Effects
Interactions
Research Summary
Developed in Japan for asthenia (chronic fatigue). Increases thiamine triphosphate in the brain. Prescribed in some countries for fatigue. Limited but positive clinical trial data.
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The Bottom Line on Sulbutiamine
Sulbutiamine is moderately researched with promising but sometimes mixed evidence.It is most commonly used for crosses blood-brain barrier effectively and may reduce mental fatigue. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Sulbutiamine
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