5-HTP
Amino AcidsKey Benefits
How It Works
5-Hydroxytryptophan is the immediate precursor to serotonin, bypassing the rate-limiting tryptophan hydroxylase step. It crosses the blood-brain barrier efficiently and converts to serotonin via aromatic amino acid decarboxylase. Serotonin then converts to melatonin for sleep.
Dosage & Timing
Recommended Dosage
50-300 mg daily
Best Time to Take
Evening for sleep, or divided doses for mood. Take with vitamin B6 for conversion.
Recommended Form
5-HTP from Griffonia simplicifolia seed extract
Side Effects
Nausea (most common), GI discomfort. Risk of serotonin syndrome with SSRIs (DANGEROUS - do not combine without medical supervision).
Drug Interactions
CRITICAL: Do NOT combine with SSRIs, SNRIs, MAOIs, or triptans. Risk of serotonin syndrome. Discuss with doctor if on any serotonergic medication.
What Does The Research Say?
Studies show efficacy for depression comparable to some SSRIs, appetite suppression for weight loss, and improved sleep. Must be taken with EGCG or carbidopa to prevent peripheral serotonin conversion. Short-term use recommended.
Where to Buy
Buy 5-HTP on Amazon
Compare prices and read reviews →
Pair Supplements With Smart Training
RYVVA tracks your workouts, nutrition, and recovery — so your supplements fuel real progress.
Try RYVVA Free →Testosterone Support From Voy
UK-based TRT and hormone optimisation. Clinician-led, delivered to your door. Blood tests, prescriptions, and ongoing monitoring.
Learn More at Voy →Try Space Goods
Nootropic mushroom blends for focus, energy, and calm. Lion\'s Mane, Cordyceps, Ashwagandha in one daily drink.
Shop Space Goods →LA Muscle Supplements
Premium sports nutrition — protein, pre-workout, testosterone boosters, and fat burners. UK-made.
Shop LA Muscle →Healthy Meals Delivered
Chef-prepared, macro-balanced meals delivered to your door. Perfect for hitting your nutrition goals.
Try Simmer Eats →Horace — Men's Skincare
Premium French skincare for men. Natural ingredients, no fuss. Cleansers, moisturisers, and grooming essentials.
Shop Horace →Vitality Health Insurance
Rewards you for being healthy. Gym discounts, Apple Watch deals, and wellness perks with your health cover.
Get a Vitality quote →Huel — Complete Nutrition
Nutritionally complete meals, shakes, and bars. 26 vitamins and minerals in every serving.
Try Huel →This information is for educational purposes only and does not constitute medical advice. Researched by the editorial team at NexoraOS, supplement user since 2018. Always consult a qualified healthcare professional before starting any supplement. Individual results may vary. Amazon links are affiliate links.