Ashwagandha
AdaptogensKey Benefits
How It Works
Ashwagandha (Withania somnifera) contains withanolides that modulate the HPA axis, reducing cortisol output. It acts as a GABAergic agent, enhancing GABA receptor activity. It also inhibits acetylcholinesterase, supports thyroid hormone conversion, and has anti-inflammatory properties.
Dosage & Timing
Recommended Dosage
300-600 mg standardised extract daily
Best Time to Take
Evening for sleep benefits, or morning for stress management
Recommended Form
KSM-66 or Sensoril standardised extracts
Side Effects
Generally well-tolerated. May cause GI discomfort, drowsiness. Rare cases of liver toxicity reported. Cycle 8 weeks on, 2 weeks off.
Drug Interactions
May enhance effects of sedatives and thyroid medications. Avoid with immunosuppressants. May lower blood sugar.
What Does The Research Say?
Multiple RCTs demonstrate significant cortisol reduction (14-28%), improved sleep quality, and enhanced VO2 max. KSM-66 and Sensoril are well-studied extracts. Recent concerns about rare hepatotoxicity warrant monitoring.
Where to Buy
Buy Ashwagandha on Amazon
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