Curcumin
PolyphenolsKey Benefits
How It Works
Curcumin inhibits NF-kB, the master inflammatory transcription factor, more effectively than many pharmaceuticals in vitro. It also modulates COX-2, LOX, TNF-alpha, and interleukins. Additional mechanisms include BDNF upregulation and amyloid plaque reduction.
Dosage & Timing
Recommended Dosage
500-2,000 mg with piperine or as phytosome/nano form
Best Time to Take
With meals containing black pepper or fat. Split doses.
Recommended Form
Longvida, Meriva (phytosome), or with BioPerine
Side Effects
Generally well-tolerated. May cause GI discomfort. Rare liver enzyme elevation with high-dose extracts. Blood-thinning effect.
Drug Interactions
Interacts with blood thinners, diabetes medications, and drugs metabolised by CYP enzymes. Enhances effects of anti-inflammatory drugs.
What Does The Research Say?
Over 12,000 published studies. Clinical trials show efficacy comparable to ibuprofen for osteoarthritis pain. Promising research for depression, metabolic syndrome, and neurodegeneration. Bioavailability is the main challenge.
Where to Buy
Buy Curcumin on Amazon
Compare prices and read reviews →
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