Melatonin
SleepKey Benefits
How It Works
Melatonin is produced by the pineal gland in response to darkness. It binds to MT1 and MT2 receptors regulating circadian rhythm. Beyond sleep, it's a potent antioxidant that enters every cell compartment including mitochondria, and has significant immunomodulatory and anti-cancer properties.
Dosage & Timing
Recommended Dosage
0.3-5 mg 30-60 minutes before bed (start lowest effective dose)
Best Time to Take
30-60 minutes before desired sleep time, in dim light
Recommended Form
Immediate-release for sleep onset, extended-release for sleep maintenance
Side Effects
Next-day grogginess at high doses. Vivid dreams. May worsen depression in some. Not habit-forming.
Drug Interactions
Interacts with blood thinners, immunosuppressants, diabetes medications, and contraceptives. May enhance sedative effects.
What Does The Research Say?
Effective for jet lag, delayed sleep phase, and shift work. Research shows 0.3-0.5 mg is often more effective than higher doses (less receptor desensitisation). Emerging research on anti-cancer properties and COVID-19 is intriguing.
Where to Buy
Buy Melatonin on Amazon
Compare prices and read reviews →
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