Niacin
VitaminsKey Benefits
How It Works
Vitamin B3 exists as nicotinic acid (niacin) and nicotinamide. Niacin uniquely activates GPR109A receptor, raising HDL by 20-30% and lowering LDL and triglycerides. Both forms are NAD+ precursors. Niacin causes vasodilation (flushing) via prostaglandin release.
Dosage & Timing
Recommended Dosage
500-2,000 mg niacin for cholesterol (50-500 mg nicotinamide for general)
Best Time to Take
With dinner to reduce flushing (which decreases with regular use)
Recommended Form
Immediate-release niacin (for lipids) or nicotinamide (for NAD+, no flush)
Side Effects
Flushing (niacin form): intense warmth, redness, itching. Liver toxicity with extended-release at high doses. GI upset.
Drug Interactions
May interact with statins, blood pressure medications, and diabetes drugs. Liver monitoring recommended at high doses.
What Does The Research Say?
Strongest evidence for HDL elevation among any supplement. AIM-HIGH and HPS2-THRIVE trials questioned cardiovascular outcomes despite lipid improvements. Nicotinamide form avoids flushing but lacks lipid benefits.
Where to Buy
Buy Niacin on Amazon
Compare prices and read reviews →
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Try Huel →This information is for educational purposes only and does not constitute medical advice. Researched by the editorial team at NexoraOS, supplement user since 2018. Always consult a qualified healthcare professional before starting any supplement. Individual results may vary. Amazon links are affiliate links.