NMN
LongevityKey Benefits
How It Works
Nicotinamide mononucleotide is a direct precursor to NAD+ via the salvage pathway enzyme NMNAT. NAD+ is essential for sirtuins (longevity genes), PARPs (DNA repair), CD38 (immune function), and hundreds of metabolic reactions. NAD+ levels decline 50% by age 50.
Dosage & Timing
Recommended Dosage
250-1,000 mg daily
Best Time to Take
Morning on empty stomach for best absorption
Recommended Form
Sublingual or enteric-coated for best absorption
Side Effects
Generally well-tolerated. Some report flushing at high doses. Long-term human safety data still accumulating.
Drug Interactions
Theoretical interaction with cancer treatment (NAD+ fuels rapidly dividing cells). No established drug interactions.
What Does The Research Say?
David Sinclair's research popularised NMN. Human trials show increased NAD+ levels, improved insulin sensitivity, and enhanced muscle function. The largest NMN trial (300mg/day) showed significant aerobic capacity improvements. Still debated vs NR.
Where to Buy
Buy NMN on Amazon
Compare prices and read reviews →
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Try Huel →This information is for educational purposes only and does not constitute medical advice. Researched by the editorial team at NexoraOS, supplement user since 2018. Always consult a qualified healthcare professional before starting any supplement. Individual results may vary. Amazon links are affiliate links.