Pregnenolone
HormonesKey Benefits
How It Works
Pregnenolone is the 'mother hormone' from which all steroid hormones derive (DHEA, progesterone, cortisol, testosterone, oestrogen). It's also a neurosteroid that enhances NMDA receptor function, supports myelination, and modulates GABA-A receptors for cognitive benefits.
Dosage & Timing
Recommended Dosage
10-50 mg daily (test levels first)
Best Time to Take
Morning to match circadian hormone production
Recommended Form
Micronised pregnenolone (pharmaceutical grade)
Side Effects
Drowsiness, irritability, headache. Hormonal effects possible. TEST LEVELS first. May cause acne or mood changes.
Drug Interactions
May interact with all hormone therapies, seizure medications, and CNS drugs. Discuss with endocrinologist.
What Does The Research Say?
Limited but promising research for cognitive enhancement, depression, and schizophrenia. As a neurosteroid, it has unique brain benefits beyond hormone conversion. Safety data is sparse for long-term use. Consider only with hormone testing.
Where to Buy
Buy Pregnenolone on Amazon
Compare prices and read reviews →
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