Riboflavin
VitaminsKey Benefits
How It Works
Vitamin B2 is the precursor to FAD and FMN, cofactors for over 100 enzymes (flavoproteins) including those in the electron transport chain, fatty acid oxidation, and the glutathione reductase antioxidant system. Essential for methylation cycle support via MTHFR enzyme.
Dosage & Timing
Recommended Dosage
25-400 mg daily (400mg for migraine prevention)
Best Time to Take
With food for better absorption. Split doses for higher amounts.
Recommended Form
Riboflavin or riboflavin-5-phosphate (active form)
Side Effects
Very safe. Causes bright yellow urine (harmless). Rare diarrhoea at very high doses.
Drug Interactions
May be depleted by oral contraceptives, TCAs, and some antibiotics.
What Does The Research Say?
Strong evidence for migraine prevention at 400mg daily (multiple RCTs). Essential for MTHFR function (supports methylation). Deficiency common in elderly and those on restricted diets.
Where to Buy
Buy Riboflavin on Amazon
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This information is for educational purposes only and does not constitute medical advice. Researched by The NexoraOS Team, supplement user since 2018. Always consult a qualified healthcare professional before starting any supplement. Individual results may vary. Amazon links are affiliate links.