Vitamin B6
VitaminsKey Benefits
How It Works
Pyridoxal-5-phosphate (P5P) is a cofactor for over 150 enzymes, primarily in amino acid metabolism. Essential for neurotransmitter synthesis (serotonin, dopamine, GABA, norepinephrine), haemoglobin formation, homocysteine to cysteine conversion, and immune cell production.
Dosage & Timing
Recommended Dosage
25-100 mg P5P daily (do not exceed 200 mg long-term)
Best Time to Take
With meals, morning or afternoon preferred
Recommended Form
Pyridoxal-5-Phosphate (P5P active form)
Side Effects
Peripheral neuropathy at chronic high doses (>200mg/day). Tingling, numbness. Photosensitivity. Use P5P form for safety.
Drug Interactions
May reduce effectiveness of levodopa and phenytoin. Depleted by oral contraceptives, isoniazid, and penicillamine.
What Does The Research Say?
P5P form is preferred (bypasses liver conversion). Commonly deficient in women on oral contraceptives. Research supports mood benefits via neurotransmitter synthesis. Essential for proper GABA function.
Where to Buy
Buy Vitamin B6 on Amazon
Compare prices and read reviews →
Pair Supplements With Smart Training
RYVVA tracks your workouts, nutrition, and recovery — so your supplements fuel real progress.
Try RYVVA Free →Testosterone Support From Voy
UK-based TRT and hormone optimisation. Clinician-led, delivered to your door. Blood tests, prescriptions, and ongoing monitoring.
Learn More at Voy →Try Space Goods
Nootropic mushroom blends for focus, energy, and calm. Lion\'s Mane, Cordyceps, Ashwagandha in one daily drink.
Shop Space Goods →LA Muscle Supplements
Premium sports nutrition — protein, pre-workout, testosterone boosters, and fat burners. UK-made.
Shop LA Muscle →Healthy Meals Delivered
Chef-prepared, macro-balanced meals delivered to your door. Perfect for hitting your nutrition goals.
Try Simmer Eats →Horace — Men's Skincare
Premium French skincare for men. Natural ingredients, no fuss. Cleansers, moisturisers, and grooming essentials.
Shop Horace →Vitality Health Insurance
Rewards you for being healthy. Gym discounts, Apple Watch deals, and wellness perks with your health cover.
Get a Vitality quote →Huel — Complete Nutrition
Nutritionally complete meals, shakes, and bars. 26 vitamins and minerals in every serving.
Try Huel →This information is for educational purposes only and does not constitute medical advice. Researched by the editorial team at NexoraOS, supplement user since 2018. Always consult a qualified healthcare professional before starting any supplement. Individual results may vary. Amazon links are affiliate links.