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Agmatine Sulfate

performance

Arginine metabolite that modulates nitric oxide and supports pain management.

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Benefits

Modulates nitric oxide synthase
May support pain management
Potential mood enhancement
Supports insulin sensitivity

Dosage

Typical Dose

500-1000mg daily

Upper Limit

250-2500mg

Timing

Pre-workout or divided doses

Forms & Bioavailability

Powder

Standard absorption

Capsule

Standard absorption

Side Effects

GI discomfort
Mild diarrhoea
Appetite changes

Interactions

Blood pressure medications
Antidepressants (SSRIs)
Opioid medications

Research Summary

Emerging research shows neuroprotective and analgesic properties. Acts as a neurotransmitter and neuromodulator. Human clinical trials are limited but animal data is promising.

The Bottom Line on Agmatine Sulfate

Agmatine Sulfate is moderately researched with promising but sometimes mixed evidence.It is most commonly used for modulates nitric oxide synthase and may support pain management. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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