Apigenin
herbs
Apigenin is a naturally occurring flavonoid found in chamomile, parsley, and other plants, known for its potential calming and antioxidant properties. It acts as a ligand for benzodiazepine receptors, suggesting possible anxiolytic and sleep-promoting effects.
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Benefits
Dosage
Typical Dose
50-100 mg daily
Upper Limit
300-500 mg daily
Timing
Evening or before bed for sleep support
Forms & Bioavailability
Powder
Moderate; improved with fat consumption due to lipophilic nature
Capsule
Moderate; standardised extracts may offer improved absorption
Side Effects
Interactions
Research Summary
Apigenin demonstrates anxiolytic and sleep-promoting properties in animal models and preliminary human studies, primarily through GABA receptor modulation. Evidence remains limited for human applications, with most research conducted in vitro or in rodent models. Additional clinical trials are needed to establish optimal dosing and efficacy in humans.
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The Bottom Line on Apigenin
Apigenin is moderately researched with promising but sometimes mixed evidence.It is most commonly used for anxiety reduction and sleep quality improvement. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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