Betaine Anhydrous TMG
amino acids
Betaine anhydrous, also known as trimethylglycine (TMG), is a naturally occurring amino acid derivative that supports methylation and homocysteine metabolism. It plays a role in cellular function, cardiovascular health, and athletic performance through its involvement in critical biochemical pathways.
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Benefits
Dosage
Typical Dose
1,000-2,500 mg daily
Upper Limit
3,000-4,000 mg daily
Timing
split doses with meals
Forms & Bioavailability
Powder
High absorption; rapid onset; easily mixed with liquids
Capsule
Good absorption; convenient dosing; consistent delivery
Tablet
Moderate absorption; shelf-stable; easy administration
Side Effects
Interactions
Research Summary
Betaine demonstrates efficacy in reducing homocysteine levels and supporting cardiovascular health in clinical studies. Research indicates potential benefits for athletic performance, muscle strength, and power output. Evidence supports its role in liver protection and methylation processes, though more long-term human trials are needed to establish optimal dosing protocols.
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The Bottom Line on Betaine Anhydrous TMG
Betaine Anhydrous TMG is moderately researched with promising but sometimes mixed evidence.It is most commonly used for homocysteine reduction and methylation support. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Betaine Anhydrous TMG
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