Cat's Claw

herbs

★★★★★

Cat's Claw (Uncaria tomentosa) is a woody vine from the Amazon rainforest traditionally used in Peruvian folk medicine. Named for its claw-shaped thorns, it contains alkaloids and polyphenols that may support immune function and joint health, though clinical evidence remains limited.

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Benefits

✓May support immune system function through alkaloid compounds

✓Traditionally used to promote joint health and mobility

✓Contains antioxidants that may reduce oxidative stress

✓May support gastrointestinal health and integrity

✓Potentially supports inflammatory response modulation

Dosage

Typical Dose

500-1000 mg daily

Upper Limit

2000 mg daily

Timing

With meals to enhance absorption and reduce gastric irritation

Forms & Bioavailability

Standardised extract (3-5% alkaloids)

High - concentrated and consistent potency

Dried bark powder

Moderate - variable alkaloid content

Liquid tincture

Moderate-High - good absorption when taken sublingually

Side Effects

⚠Gastrointestinal upset, nausea, or diarrhoea in sensitive individuals

⚠Dizziness or headaches reported at higher doses

⚠Allergic reactions possible in individuals sensitive to Rubiaceae family plants

Interactions

⚡May potentiate immunosuppressant medications and interfere with immunosuppressive therapy

⚡Potential interaction with anticoagulants due to possible mild antiplatelet properties

⚡May interact with medications metabolised by CYP3A4 enzyme system

Research Summary

Evidence is predominantly from traditional use and in vitro studies. Several small clinical trials suggest potential benefits for joint comfort and immune support, but larger, well-controlled human studies are needed. The alkaloid composition varies significantly between sources, affecting consistency of results.

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The Bottom Line on Cat's Claw

Cat's Claw is moderately researched with promising but sometimes mixed evidence.It is most commonly used for may support immune system function through alkaloid compounds and traditionally used to promote joint health and mobility. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Goal Guides for Cat's Claw

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.