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Cissus Quadrangularis

herbs

Cissus quadrangularis, also known as vétch or devil's backbone, is a tropical plant traditionally used in Ayurvedic and African medicine. It contains stilbenes and flavonoids that may support bone health, joint function, and metabolic processes.

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Benefits

Bone health support
Joint integrity
Fracture healing
Metabolic function
Antioxidant activity

Dosage

Typical Dose

300–500 mg daily

Upper Limit

1200 mg daily

Timing

With meals for optimal absorption

Forms & Bioavailability

Standardised extract (10% ketosteroids)

Enhanced absorption; most researched form

Powder

Moderate; variable potency depending on source

Capsules

Good; consistent dosing

Side Effects

Mild gastrointestinal upset
Headache (rare)
Dizziness (rare)

Interactions

May potentiate anticoagulants and antiplatelet agents
Possible interactions with diabetes medications

Research Summary

Clinical evidence supports Cissus quadrangularis for bone healing and joint support, particularly in fracture recovery and osteoarthritis. Studies suggest its ketosteroid and polyphenol content contributes to these effects, though human research remains limited compared to animal models. Additional long-term safety and efficacy studies are needed.

The Bottom Line on Cissus Quadrangularis

Cissus Quadrangularis is moderately researched with promising but sometimes mixed evidence.It is most commonly used for bone health support and joint integrity. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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