Citicoline (CDP-Choline)
nootropics
Endogenous brain nutrient providing both choline and cytidine for neuroprotection.
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Benefits
Dosage
Typical Dose
250-500mg daily
Upper Limit
200-2000mg
Timing
Morning or divided doses
Forms & Bioavailability
Capsule
Standard absorption
Powder
Standard absorption
Side Effects
Interactions
Research Summary
Extensively studied with strong clinical evidence for cognitive enhancement, stroke recovery, and neuroprotection. Cognizin branded form used in major RCTs. FDA GRAS status.
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The Bottom Line on Citicoline (CDP-Choline)
Citicoline (CDP-Choline) is well-researched with strong evidence supporting its primary benefits.It is most commonly used for provides choline and cytidine to the brain and supports phosphatidylcholine synthesis. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Citicoline (CDP-Choline)
See how Citicoline (CDP-Choline) can help with specific health goals: