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DIM (Diindolylmethane)

hormonal support

Cruciferous vegetable compound that promotes healthy estrogen metabolism.

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Benefits

Promotes favourable 2-OH estrogen metabolites
Supports hormonal balance
May reduce estrogen dominance symptoms
Supports healthy cell growth

Dosage

Typical Dose

100-200mg daily

Upper Limit

100-400mg

Timing

With meals containing fat

Forms & Bioavailability

Capsule

Standard absorption

Softgel

Standard absorption

Side Effects

Darkened urine
Headache
Changes in menstrual cycle
GI upset

Interactions

Hormone therapies
Tamoxifen
CYP1A2 substrates

Research Summary

Well-studied metabolite of indole-3-carbinol from cruciferous vegetables. Shifts estrogen metabolism toward protective 2-hydroxy pathway. Clinical trials support use in cervical dysplasia and hormonal balance.

The Bottom Line on DIM (Diindolylmethane)

DIM (Diindolylmethane) is well-researched with strong evidence supporting its primary benefits.It is most commonly used for promotes favourable 2-oh estrogen metabolites and supports hormonal balance. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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