I3C Indole-3-Carbinol
herbs
I3C is a naturally occurring compound found in cruciferous vegetables like broccoli and cabbage that supports oestrogen metabolism and detoxification. It is converted in the stomach to diindolylmethane (DIM), which is believed to promote balanced hormone levels and antioxidant activity.
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Benefits
Dosage
Typical Dose
200-400 mg daily
Upper Limit
up to 800 mg daily
Timing
With meals to improve absorption
Forms & Bioavailability
Capsule
Good absorption when taken with food; conversion to DIM occurs in the stomach
Powder
Variable depending on stomach pH and food intake
Side Effects
Interactions
Research Summary
Research suggests I3C and its metabolite DIM may help modulate oestrogen metabolism, though human studies remain limited. Most evidence comes from in vitro and animal studies, with promising but preliminary results for hormonal and detoxification support. Further clinical trials are needed to establish efficacy and optimal dosing protocols in humans.
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The Bottom Line on I3C Indole-3-Carbinol
I3C Indole-3-Carbinol is moderately researched with promising but sometimes mixed evidence.It is most commonly used for supports oestrogen metabolism and promotes liver detoxification. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for I3C Indole-3-Carbinol
See how I3C Indole-3-Carbinol can help with specific health goals: