L-Lysine
amino acids
L-Lysine is an essential amino acid crucial for protein synthesis, collagen formation, and immune function. It is particularly notable for its role in managing herpes simplex virus (HSV) infections and supporting bone health. The body cannot synthesise lysine, making dietary intake or supplementation necessary.
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Benefits
Dosage
Typical Dose
1,000-3,000 mg daily
Upper Limit
6,000 mg daily
Timing
With meals; split doses for better absorption
Forms & Bioavailability
L-Lysine monohydrochloride
High absorption; commonly used supplement form with good intestinal uptake
L-Lysine base
Similar absorption to monohydrochloride; gentler on stomach
Dietary sources
Excellent bioavailability; found in meat, fish, eggs, dairy, and legumes
Side Effects
Interactions
Research Summary
Clinical studies demonstrate L-lysine's effectiveness in reducing HSV-1 recurrence frequency by approximately 40% and shortening outbreak duration. Research supports its role in collagen synthesis and bone metabolism, with evidence suggesting benefits for bone health and wound healing. Additional studies indicate potential immune-supporting properties, though more research is needed on optimal dosing protocols.
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The Bottom Line on L-Lysine
L-Lysine is well-researched with strong evidence supporting its primary benefits.It is most commonly used for supports immune function and antibody production and may reduce frequency and severity of cold sores. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for L-Lysine
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