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Lactoferrin

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Lactoferrin is an iron-binding glycoprotein found naturally in milk and other bodily secretions that plays a role in immune function and iron metabolism. It has been studied for its potential antimicrobial and anti-inflammatory properties.

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Benefits

Immune system support
Iron absorption regulation
Antimicrobial activity
Gut health maintenance
Inflammation reduction

Dosage

Typical Dose

100-300 mg daily

Upper Limit

600 mg daily

Timing

With or without food, preferably with meals

Forms & Bioavailability

Bovine Lactoferrin Powder

Moderate; best absorbed on empty stomach but often taken with food for tolerance

Lactoferrin Capsules

Moderate; enteric-coated forms may improve delivery to intestines

Side Effects

Gastrointestinal upset
Nausea
Constipation
Allergic reactions in dairy-sensitive individuals

Interactions

Iron supplements may compete for absorption
May interact with medications affecting iron metabolism
Potential interactions with immunosuppressant drugs

Research Summary

Research suggests lactoferrin exhibits antimicrobial and immunomodulatory properties, with some evidence for supporting respiratory and gastrointestinal health. However, human clinical trials remain limited, and most findings are from in vitro or animal studies. Additional well-designed clinical trials are needed to establish efficacy and optimal dosing.

The Bottom Line on Lactoferrin

Lactoferrin is moderately researched with promising but sometimes mixed evidence.It is most commonly used for immune system support and iron absorption regulation. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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