Lumbrokinase
herbs
Lumbrokinase is a fibrinolytic enzyme derived from earthworm (Lumbricus rubellus) that breaks down fibrin and supports circulatory health. It is traditionally used in Asian medicine to improve blood flow and reduce clot formation. Research on its efficacy in Western medicine remains limited and ongoing.
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Benefits
Dosage
Typical Dose
300-600 mg daily (20,000-40,000 units)
Upper Limit
1,200 mg daily in divided doses
Timing
On an empty stomach or with meals; consistency recommended
Forms & Bioavailability
Capsules
Moderate (enteric-coated recommended)
Tablets
Moderate
Powder
Variable
Side Effects
Interactions
Research Summary
Lumbrokinase has been studied in Asian clinical trials for cardiovascular and thrombotic conditions, with some positive results; however, most studies lack rigorous methodological standards by Western medical criteria. Limited peer-reviewed research exists in mainstream Western literature, and most evidence remains preliminary or unpublished. Further high-quality randomised controlled trials are needed to establish safety and efficacy in diverse populations.
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The Bottom Line on Lumbrokinase
Lumbrokinase is moderately researched with promising but sometimes mixed evidence.It is most commonly used for supports fibrinolysis and may reduce excessive blood clotting and may improve circulation and blood flow. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Lumbrokinase
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