SP
StackPedia
All Supplements

Manganese

minerals

Manganese is an essential trace mineral critical for bone development, metabolism, and antioxidant defence through the enzyme manganese superoxide dismutase (MnSOD). It plays important roles in collagen synthesis, wound healing, and blood sugar regulation, though deficiency is rare in developed countries due to adequate dietary intake.

Benefits

Supports bone health and mineralisation
Enhances antioxidant defence via MnSOD enzyme
Promotes wound healing and collagen formation
Aids carbohydrate and fat metabolism
Supports joint health and cartilage maintenance

Dosage

Typical Dose

1.8–2.3 mg daily

Upper Limit

11 mg daily (tolerable upper intake level)

Timing

With meals to enhance absorption

Forms & Bioavailability

Manganese gluconate

Well-absorbed form commonly used in supplements

Manganese citrate

Good bioavailability with minimal GI irritation

Manganese sulphate

Highly absorbable but may cause gastrointestinal upset at high doses

Side Effects

Excessive intake can cause neurotoxicity and tremors
Gastrointestinal upset (nausea, constipation)
Occupational exposure linked to manganism (Parkinson's-like symptoms)

Interactions

Iron, calcium, and magnesium may competitively inhibit manganese absorption
Tea and coffee polyphenols can reduce bioavailability
May interact with antipsychotic medications at very high doses

Research Summary

Manganese is essential for numerous enzymatic processes and bone health, with most evidence supporting its role in skeletal development and antioxidant metabolism. Research indicates that deficiency is uncommon in populations with adequate dietary intake, though supplementation may benefit individuals with specific absorption issues or joint concerns. Excessive supplementation should be avoided due to potential neurotoxic effects, particularly from inhaled occupational exposure.

Where to Buy Manganese

We recommend buying from reputable retailers. Check reviews and third-party testing.

Affiliate links — we may earn a commission at no extra cost to you.

Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.