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Norvaline

performance

Arginase inhibitor that may prolong nitric oxide production for better pumps.

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Benefits

Inhibits arginase to preserve arginine
May prolong nitric oxide production
Supports sustained muscle pumps
Often stacked with citrulline

Dosage

Typical Dose

100-200mg pre-workout

Upper Limit

100-400mg

Timing

Pre-workout

Forms & Bioavailability

Powder

Standard absorption

Capsule

Standard absorption

Side Effects

Limited safety data
Possible neurotoxicity concerns at high chronic doses

Interactions

Blood pressure medications
Other NO boosters

Research Summary

Mechanism of arginase inhibition is established in vitro. Human performance studies are very limited. Some safety concerns raised in a 2019 study regarding potential neurotoxicity at high doses.

The Bottom Line on Norvaline

Norvaline is emerging in research with limited but interesting evidence.It is most commonly used for inhibits arginase to preserve arginine and may prolong nitric oxide production. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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