Omega-3 (EPA/DHA)

amino acids

★★★★★

Essential fatty acids found in fatty fish. Anti-inflammatory, cardiovascular protective, and important for brain health.

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Benefits

✓Heart health — reduces triglycerides

✓Brain function and mental clarity

✓Anti-inflammatory effects

✓Joint health

✓May reduce depression symptoms (EPA specifically)

Dosage

Typical Dose

1-2g combined EPA/DHA daily

Upper Limit

5g daily

Timing

With meals containing fat

Forms & Bioavailability

Fish Oil (Triglyceride form)

High — natural form, well absorbed

Krill Oil

High — phospholipid-bound, may be better absorbed per mg

Algae Oil (DHA)

Good — vegan source, mainly DHA

Ethyl Ester

Moderate — cheaper but less well absorbed

Side Effects

⚠Fish burps (use enteric-coated capsules)

⚠Mild blood thinning at high doses

⚠Rare: fishy aftertaste

Interactions

⚡Blood thinners (warfarin, aspirin) — increases bleeding risk

⚡Blood pressure medications — additive effect

⚡Consult doctor if on anticoagulants

Research Summary

Extensive evidence for cardiovascular benefits. REDUCE-IT trial showed 25% reduction in cardiovascular events with high-dose EPA. Strong evidence for triglyceride reduction. Moderate evidence for depression (EPA-dominant formulas).

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The Bottom Line on Omega-3 (EPA/DHA)

Omega-3 (EPA/DHA) is well-researched with strong evidence supporting its primary benefits.It is most commonly used for heart health — reduces triglycerides and brain function and mental clarity. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Goal Guides for Omega-3 (EPA/DHA)

See how Omega-3 (EPA/DHA) can help with specific health goals:

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.