Ornithine
amino acids
Ornithine is a non-essential amino acid that plays a crucial role in the urea cycle and ammonia detoxification. It is commonly used as a supplement to support muscle growth, athletic performance, and immune function.
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Benefits
Dosage
Typical Dose
2-3 grams daily
Upper Limit
10 grams daily
Timing
Between meals or before bed for optimal absorption
Forms & Bioavailability
L-Ornithine
Standard form with good oral absorption
Ornithine alpha-ketoglutarate (OKG)
Enhanced form with improved bioavailability and metabolic activity
Side Effects
Interactions
Research Summary
Research demonstrates that ornithine supplementation may enhance growth hormone release and support muscle recovery in athletes. Studies suggest benefits for immune function and wound healing, though evidence is mixed regarding athletic performance improvements. Further long-term safety and efficacy studies are needed to establish optimal dosing protocols.
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The Bottom Line on Ornithine
Ornithine is moderately researched with promising but sometimes mixed evidence.It is most commonly used for muscle protein synthesis and growth hormone stimulation. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Ornithine
See how Ornithine can help with specific health goals: