Pau D'Arco

herbs

★★★★★

Pau D'Arco is a herbal supplement derived from the inner bark of the Tabebuia tree native to South America. It contains lapachol and beta-lapachone, compounds traditionally used for immune support and antimicrobial properties. Scientific evidence supporting its efficacy remains limited.

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Benefits

✓Potential antimicrobial and antifungal support

✓May support immune system function

✓Traditional use for inflammatory conditions

✓Possible antioxidant activity

✓Historically used for candida management

Dosage

Typical Dose

500-1000 mg daily

Upper Limit

3000 mg daily

Timing

With meals to minimise gastrointestinal upset

Forms & Bioavailability

Bark decoction

High

Dried bark powder

Moderate

Capsules/tablets

Moderate

Liquid extract

High

Side Effects

⚠Gastrointestinal distress, nausea, and dizziness at higher doses

⚠Potential bone marrow suppression with prolonged use

⚠Allergic reactions in sensitive individuals

Interactions

⚡May potentiate anticoagulants and antiplatelet medications

⚡Possible interaction with chemotherapy agents

⚡May affect blood glucose levels in diabetic patients

Research Summary

Limited clinical evidence in humans; most studies are in vitro or animal models. Some research suggests antimicrobial properties, but robust human trials are lacking. The active compound lapachol showed toxicity concerns in historical research, limiting its widespread medical application.

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The Bottom Line on Pau D'Arco

Pau D'Arco is moderately researched with promising but sometimes mixed evidence.It is most commonly used for potential antimicrobial and antifungal support and may support immune system function. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.