Phenylethylamine (PEA)
nootropics
Phenylethylamine is an endogenous trace amine that functions as a neuromodulator, promoting dopamine and noradrenaline release in the brain. Often called the 'love chemical', it may enhance mood, motivation, and mental focus. However, it is rapidly metabolised by monoamine oxidase (MAO) enzymes, limiting its bioavailability and effectiveness as an oral supplement.
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Benefits
Dosage
Typical Dose
500-2000 mg per dose
Upper Limit
3000 mg per day
Timing
30-60 minutes before mental tasks; avoid evening use
Forms & Bioavailability
Standard PEA powder
Low (5-10%)
PEA with MAO inhibitors (stacked)
Moderate (20-30%)
Capsules
Low (5-10%)
Side Effects
Interactions
Research Summary
PEA is produced naturally in the brain and is associated with mood and pleasure, but oral supplementation has limited clinical evidence. Most human studies show minimal benefit due to rapid hepatic metabolism via MAO enzymes. Research remains preliminary, with more rigorous trials needed to establish efficacy and safety profiles.
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The Bottom Line on Phenylethylamine (PEA)
Phenylethylamine (PEA) is moderately researched with promising but sometimes mixed evidence.It is most commonly used for mood elevation and euphoric effects and enhanced mental focus and concentration. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Phenylethylamine (PEA)
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