Phosphatidylserine
nootropics
Phosphatidylserine is a phospholipid compound found in cell membranes that plays a crucial role in cognitive function and stress response. It is particularly concentrated in brain tissue and has been studied for its potential to support memory, focus, and emotional wellbeing.
Benefits
Dosage
Typical Dose
100-200mg daily
Upper Limit
600mg daily
Timing
With meals for optimal absorption
Forms & Bioavailability
Phosphatidylserine (soy-derived)
Moderate; better absorbed when taken with fat-containing meals
Phosphatidylserine (bovine cortex-derived)
Moderate; historically used but less common; similar absorption to plant-derived forms
Side Effects
Interactions
Research Summary
Clinical studies show phosphatidylserine may improve cognitive performance and reduce age-related memory decline, particularly in older adults. Research suggests it can modulate cortisol response during stress, supporting emotional resilience. However, evidence quality varies, and additional large-scale studies are needed to confirm optimal dosing and long-term efficacy.
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