Phosphatidylserine
nootropics
Phosphatidylserine is a phospholipid compound found in cell membranes that plays a crucial role in cognitive function and stress response. It is particularly concentrated in brain tissue and has been studied for its potential to support memory, focus, and emotional wellbeing.
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Benefits
Dosage
Typical Dose
100-200mg daily
Upper Limit
600mg daily
Timing
With meals for optimal absorption
Forms & Bioavailability
Phosphatidylserine (soy-derived)
Moderate; better absorbed when taken with fat-containing meals
Phosphatidylserine (bovine cortex-derived)
Moderate; historically used but less common; similar absorption to plant-derived forms
Side Effects
Interactions
Research Summary
Clinical studies show phosphatidylserine may improve cognitive performance and reduce age-related memory decline, particularly in older adults. Research suggests it can modulate cortisol response during stress, supporting emotional resilience. However, evidence quality varies, and additional large-scale studies are needed to confirm optimal dosing and long-term efficacy.
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The Bottom Line on Phosphatidylserine
Phosphatidylserine is moderately researched with promising but sometimes mixed evidence.It is most commonly used for supports memory and cognitive function and may reduce cortisol levels and stress response. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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