Phosphatidylserine Complex
nootropics
Phosphatidylserine is a phospholipid naturally found in cell membranes, particularly abundant in the brain, that supports cognitive function and stress resilience. This complex typically combines phosphatidylserine with complementary ingredients to enhance neuroprotection and mental performance. It has been studied for its potential to support memory, focus, and emotional wellbeing.
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Benefits
Dosage
Typical Dose
100-200 mg daily
Upper Limit
600 mg daily
Timing
With meals for optimal absorption; morning or split doses
Forms & Bioavailability
Phosphatidylserine (soy-derived)
Moderate (20-30%)
Phosphatidylserine (bovine cortex-derived)
High (35-40%)
Phosphatidylserine Complex (with cofactors)
High (40-50%)
Side Effects
Interactions
Research Summary
Clinical studies have demonstrated phosphatidylserine's efficacy in supporting memory and cognitive performance, particularly in ageing populations, with several randomised controlled trials showing improvements in memory retention and recall. Research indicates it may help modulate stress hormones and support emotional wellbeing, though evidence is more modest for this application. The evidence base is strongest for cognitive support, with over 100 peer-reviewed studies documenting its safety and efficacy profile.
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The Bottom Line on Phosphatidylserine Complex
Phosphatidylserine Complex is well-researched with strong evidence supporting its primary benefits.It is most commonly used for supports memory recall and cognitive function and may reduce cortisol levels and support stress management. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Phosphatidylserine Complex
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