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Resveratrol

herbs

Resveratrol is a polyphenolic compound found primarily in red grapes, berries, and red wine that acts as a natural antioxidant and activates sirtuin pathways. It has been extensively studied for its potential anti-ageing, cardiovascular, and neuroprotective properties.

Benefits

Antioxidant and anti-inflammatory support
Cardiovascular health and endothelial function
Sirtuin activation and cellular longevity
Neuroprotection and cognitive support
Blood sugar regulation and metabolic health

Dosage

Typical Dose

150-500 mg daily

Upper Limit

1,500 mg daily

Timing

With meals to enhance absorption; split doses may improve bioavailability

Forms & Bioavailability

Standard powder/capsule

Low bioavailability (~20%), rapidly metabolised and conjugated in the liver

Trans-resveratrol

More stable and bioavailable form than cis-resveratrol; enhanced absorption with fatty meals

Micronised/liposomal formulations

Improved absorption and tissue penetration compared to standard forms

Side Effects

Gastrointestinal upset and mild nausea at higher doses
Headaches and dizziness
Potential oestrogen-like effects in sensitive individuals

Interactions

May potentiate anticoagulants and antiplatelet agents (warfarin, aspirin)
Potential interaction with cytochrome P450 enzymes affecting drug metabolism
May interact with blood pressure medications

Research Summary

Clinical evidence demonstrates resveratrol's cardiovascular and antioxidant benefits, with promising results in small studies on inflammation and metabolic health. However, poor oral bioavailability limits its efficacy, and larger, well-controlled human trials are needed to confirm anti-ageing claims observed in cell and animal models. Most benefits remain theoretical in humans, with modest effects demonstrated in clinical practice.

Where to Buy Resveratrol

We recommend buying from reputable retailers. Check reviews and third-party testing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.