Synephrine
herbs
Synephrine is a naturally occurring alkaloid found in bitter orange (Citrus aurantium) that functions as a sympathomimetic compound similar to ephedrine. It is commonly used in weight management and energy supplements to support metabolism and fat oxidation.
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Benefits
Dosage
Typical Dose
20-50 mg per dose
Upper Limit
100 mg daily
Timing
30-60 minutes before exercise or meals
Forms & Bioavailability
Bitter orange extract
Variable; typically 5-10% synephrine content by weight
Standardised powder
Higher and more consistent when standardised to 6% synephrine or greater
Capsules
Moderate; absorption dependent on formulation and standardisation
Side Effects
Interactions
Research Summary
Research suggests synephrine modestly increases metabolic rate and fat oxidation, with some studies showing 3-5% increases in energy expenditure. However, evidence for significant weight loss is limited and inconsistent. Safety concerns exist regarding cardiovascular effects, particularly when combined with other stimulants.
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The Bottom Line on Synephrine
Synephrine is moderately researched with promising but sometimes mixed evidence.It is most commonly used for metabolic rate enhancement and energy and alertness support. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for Synephrine
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