TMG (Trimethylglycine)
amino acids
TMG is a naturally occurring amino acid derivative that serves as a methyl donor in cellular methylation processes, supporting cardiovascular health and homocysteine metabolism. It is found in small quantities in foods like beetroot, spinach, and whole grains, and is commonly used as a dietary supplement to optimise methylation pathways.
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Benefits
Dosage
Typical Dose
500-2000 mg daily
Upper Limit
3000 mg daily
Timing
With meals for optimal absorption; divide doses throughout the day
Forms & Bioavailability
TMG powder
High
TMG capsules
High
Betaine hydrochloride (HCl form)
Very high
Side Effects
Interactions
Research Summary
Research suggests TMG effectively reduces homocysteine levels, a known cardiovascular risk factor, in several clinical trials. Studies indicate potential benefits for exercise performance and endurance in athletic populations, though evidence remains modest. More rigorous long-term safety and efficacy studies are needed to fully establish optimal dosing and clinical applications beyond homocysteine management.
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The Bottom Line on TMG (Trimethylglycine)
TMG (Trimethylglycine) is moderately researched with promising but sometimes mixed evidence.It is most commonly used for supports homocysteine metabolism and cardiovascular health and enhances cellular methylation processes. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.
About Our Research
This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.
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Goal Guides for TMG (Trimethylglycine)
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