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Vitamin B3 (Niacin)

vitamins

Vitamin B3, also known as niacin or nicotinic acid, is an essential water-soluble B vitamin crucial for energy metabolism and DNA repair. It plays a vital role in converting food into usable energy and supports cardiovascular and neurological health. Niacin is naturally found in meat, fish, nuts, and whole grains.

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Benefits

Energy production and metabolism
DNA repair and cellular health
Cardiovascular health and cholesterol support
Brain function and cognitive support
Skin health and nervous system function

Dosage

Typical Dose

14-16 mg daily

Upper Limit

35 mg daily (tolerable upper limit)

Timing

With meals to minimise flushing

Forms & Bioavailability

Nicotinic acid (niacin)

Causes flushing but effective; well-absorbed

Niacinamide (nicotinamide)

No-flush alternative; excellent absorption

Inositol hexanicotinate

Extended-release, minimal flushing

Side Effects

Niacin flush (harmless but uncomfortable)
Gastrointestinal upset
Liver toxicity at very high doses
Glucose intolerance
Gout exacerbation

Interactions

Alcohol increases flushing risk
Statins may increase niacin effects
Anticoagulants may interact
Diabetes medications require monitoring

Research Summary

Niacin is well-established for supporting energy metabolism and has demonstrated benefits for cardiovascular health, particularly in improving cholesterol profiles. Research supports its role in preventing pellagra and supporting cognitive function, though megadoses should only be used under medical supervision. Studies continue to investigate its potential in neurological and metabolic disorders.

The Bottom Line on Vitamin B3 (Niacin)

Vitamin B3 (Niacin) is well-researched with strong evidence supporting its primary benefits.It is most commonly used for energy production and metabolism and dna repair and cellular health. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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