Magnesium L-Threonate vs Vitamin B12 — Which Should You Take?
Magnesium L-Threonate Benefits
Vitamin B12 Benefits
Magnesium L-Threonate Side Effects
Vitamin B12 Side Effects
Can You Take Magnesium L-Threonate and Vitamin B12 Together?
In most cases, Magnesium L-Threonate and Vitamin B12 can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication or have existing health conditions.
Magnesium L-Threonate: Safe with most supplements
Magnesium L-Threonate: May enhance effects of sleep aids
Vitamin B12: Metformin reduces B12 absorption — supplement if on metformin
Vitamin B12: Proton pump inhibitors (PPIs) reduce absorption
Which Should You Choose?
Choose Magnesium L-Threonate if your primary goal is: crosses blood-brain barrier. Choose Vitamin B12 if your primary goal is: energy production.
Affiliate links — we may earn a small commission at no extra cost to you.
Frequently Asked Questions
Is Magnesium L-Threonate better than Vitamin B12?
It depends on your goals. Magnesium L-Threonate and Vitamin B12 serve different purposes and are often taken together.
Can I take Magnesium L-Threonate and Vitamin B12 together?
In most cases, yes. Magnesium L-Threonate and Vitamin B12 can be taken together safely. However, always check for specific interactions and consult a healthcare professional if you take medication.
What is the best time to take Magnesium L-Threonate?
Evening — has calming/sleep-promoting effects
What is the best time to take Vitamin B12?
Morning — may be energising
What are the side effects of Magnesium L-Threonate?
Drowsiness. Headache in some people initially. Low elemental magnesium per dose — may need additional Mg source.
What are the side effects of Vitamin B12?
Very safe — excess excreted in urine. Rare: acne at very high doses in some individuals.
How We Compare Supplements
This comparison is based on published clinical research, peer-reviewed studies from PubMed, and established nutritional science. We evaluate dosages based on clinically-effective amounts, not manufacturer recommendations. Benefits listed have at least moderate evidence from human studies. When evidence is limited or conflicting, we note this.