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Magnesium L-Threonate

nootropics

A form of magnesium specifically developed to cross the blood-brain barrier. Researched for cognitive function, memory, and brain ageing.

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Benefits

Crosses blood-brain barrier
May improve memory and learning
Sleep quality improvement
Brain magnesium levels
Potential neuroprotective effects

Dosage

Typical Dose

1,500-2,000mg (providing ~144mg elemental Mg)

Upper Limit

2,000mg daily

Timing

Evening — has calming/sleep-promoting effects

Forms & Bioavailability

Magnesium L-Threonate (Magtein)

High brain bioavailability — patented form

Side Effects

Drowsiness
Headache in some people initially
Low elemental magnesium per dose — may need additional Mg source

Interactions

Safe with most supplements
May enhance effects of sleep aids
Does not replace need for other magnesium forms for muscle/general health

Research Summary

MIT-developed compound. One key RCT showed improved cognitive abilities in older adults. Limited but promising research. More studies needed to confirm benefits.

The Bottom Line on Magnesium L-Threonate

Magnesium L-Threonate is moderately researched with promising but sometimes mixed evidence.It is most commonly used for crosses blood-brain barrier and may improve memory and learning. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.

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