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Nattokinase vs Magnesium — Which Should You Take?

Nattokinase

★★★★★

herbs

Typically £8–£25/month

Magnesium

★★★★★

minerals

Typically £8–£25/month
Feature
Nattokinase
Magnesium
Typical Dosage
2000 FU (fibrinolytic units) daily
200-400mg elemental magnesium daily
Best Form
Capsule (standardised extract)
Magnesium Glycinate
Key Benefits
5 listed
5 listed
Evidence Rating
★★★★★
★★★★★
Best Time
On an empty stomach, 2-4 hours before or after meals for optimal absorption
Evening for sleep benefits, split doses for absorption
Upper Limit
4000 FU daily
800mg daily
Side Effects
3 noted
3 noted

Nattokinase Benefits

✓May support healthy blood circulation and fibrinolysis
✓Potential cardiovascular health maintenance
✓May help reduce blood viscosity
✓Possible support for healthy clotting balance
✓Traditional use in Japanese medicine for vitality

Magnesium Benefits

✓Sleep quality improvement
✓Muscle relaxation and cramp prevention
✓Stress and anxiety reduction
✓Blood pressure regulation
✓Energy production

Nattokinase Side Effects

⚠Rare mild gastrointestinal upset or nausea
⚠Potential increased bleeding risk at high doses, particularly in susceptible individuals
⚠Allergic reactions in those with soy sensitivity

Magnesium Side Effects

⚠Loose stools (especially citrate/oxide forms)
⚠Rare: low blood pressure at very high doses
⚠Generally very safe

Can You Take Nattokinase and Magnesium Together?

In most cases, Nattokinase and Magnesium can be taken together safely. However, always check the interactions section of each supplement and consult a healthcare professional if you take medication or have existing health conditions.

Nattokinase: May potentiate anticoagulants (warfarin, apixaban) and antiplatelet agents (aspirin, clopidogrel)

Nattokinase: Potential interaction with blood pressure medications

Magnesium: May reduce absorption of antibiotics (tetracyclines, quinolones)

Magnesium: Can interact with blood pressure medications

Which Should You Choose?

Choose Nattokinase if your primary goal is: may support healthy blood circulation and fibrinolysis. Choose Magnesium if your primary goal is: sleep quality improvement.

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Frequently Asked Questions

Is Nattokinase better than Magnesium?

It depends on your goals. Nattokinase and Magnesium serve different purposes and are often taken together.

Can I take Nattokinase and Magnesium together?

In most cases, yes. Nattokinase and Magnesium can be taken together safely. However, always check for specific interactions and consult a healthcare professional if you take medication.

What is the best time to take Nattokinase?

On an empty stomach, 2-4 hours before or after meals for optimal absorption

What is the best time to take Magnesium?

Evening for sleep benefits, split doses for absorption

What are the side effects of Nattokinase?

Rare mild gastrointestinal upset or nausea. Potential increased bleeding risk at high doses, particularly in susceptible individuals. Allergic reactions in those with soy sensitivity.

What are the side effects of Magnesium?

Loose stools (especially citrate/oxide forms). Rare: low blood pressure at very high doses. Generally very safe.

How We Compare Supplements

This comparison is based on published clinical research, peer-reviewed studies from PubMed, and established nutritional science. We evaluate dosages based on clinically-effective amounts, not manufacturer recommendations. Benefits listed have at least moderate evidence from human studies. When evidence is limited or conflicting, we note this.

Disclaimer: This comparison is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before starting any supplement, especially if you take medication or have existing health conditions.

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