Nattokinase

herbs

★★★★★

Nattokinase is a serine protease enzyme derived from natto, a traditional Japanese fermented soybean food. It has been studied for its potential fibrinolytic properties and cardiovascular support benefits.

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Benefits

✓May support healthy blood circulation and fibrinolysis

✓Potential cardiovascular health maintenance

✓May help reduce blood viscosity

✓Possible support for healthy clotting balance

✓Traditional use in Japanese medicine for vitality

Dosage

Typical Dose

2000 FU (fibrinolytic units) daily

Upper Limit

4000 FU daily

Timing

On an empty stomach, 2-4 hours before or after meals for optimal absorption

Forms & Bioavailability

Capsule (standardised extract)

High

Powder

Moderate

Whole natto food

Moderate to Low

Side Effects

⚠Rare mild gastrointestinal upset or nausea

⚠Potential increased bleeding risk at high doses, particularly in susceptible individuals

⚠Allergic reactions in those with soy sensitivity

Interactions

⚡May potentiate anticoagulants (warfarin, apixaban) and antiplatelet agents (aspirin, clopidogrel)

⚡Potential interaction with blood pressure medications

⚡May interact with other fibrinolytic supplements or enzymes

Research Summary

Several small human studies suggest nattokinase may support fibrinolytic activity and blood flow, though evidence remains limited and mixed. Most research has been conducted in Japan, and larger, well-controlled Western studies are needed to substantiate health claims. The enzyme's stability in the gastrointestinal tract and systemic bioavailability remain areas of scientific debate.

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The Bottom Line on Nattokinase

Nattokinase is moderately researched with promising but sometimes mixed evidence.It is most commonly used for may support healthy blood circulation and fibrinolysis and potential cardiovascular health maintenance. As with any supplement, individual results vary. Start with the lower end of the dosage range and assess for 4-8 weeks before adjusting.

About Our Research

This profile is compiled from peer-reviewed research published on PubMed, the NIH Office of Dietary Supplements, and established nutritional science databases. Dosages reflect clinically-studied amounts from human trials where available. We update profiles as new research emerges. This is not medical advice — consult a healthcare professional before supplementing.

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Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement, especially if you have existing health conditions or take medication.